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中文名稱： 兔抗NFKBIE多克隆抗體
英文名稱： Anti-NFKBIE rabbit polyclonal antibody
別 名： IKBE
相關(guān)類別： 一抗
抗 原： NFKBIE
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
反應(yīng)種屬： Human, Mouse
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
NFKBIE |
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Immunogen: |
Fusion protein of human NFKBIE |
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Full name: |
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon |
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Synonyms： |
IKBE |
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SwissProt: |
O00221 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human lymphoma and Human esophagus cancer |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
45 kDa |
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WB Positive control: |
PC3 cells |
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WB Recommended dilution: |
200-1000 |
